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N-Acetylneuraminic acid Europäischer Partner

ArtNr HY-I0400-10mM
Hersteller MedChem Express
CAS-Nr. 131-48-6
Menge 10mM/1mL
Quantity options 100 mg 10mM/1mL 1 g
Kategorie
Typ Inhibitors
Specific against other
Purity 99.90
Formula C11H19NO9
Citations [1]Kiefel MJ, et al. Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors[J]. J Med Chem. 1996 Mar 15;39(6):1314-20.
[2]Yoshikawa, K., et al. N-Acetylneuraminic Acid Inhibits Melanogenesis via Induction of Autophagy[J]. Cosmetics 2024, 11, 82.
[3]Zhang L, et al. Functional Metabolomics Characterizes a Key Role for N-Acetylneuraminic Acid in Coronary Artery Diseases[J]. Circulation. 2018 Mar 27;137(13):1374-1390.
[4]Yida Z, et al. High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats[J]. J Biomed Sci. 2015 Oct 24;22:96.
Smiles OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](NC(C)=O)[C@@H](O)CC(C(O)=O)=O
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias NANA; Lactaminic acid
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Natural Products
Manufacturer - Applications
COVID-19-anti-virus
Manufacturer - Targets
Endogenous Metabolite; Influenza Virus; Ras; Tyrosinase
Shipping Temperature
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Molecular Weight
309.27
Product Description
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia[1][2][3][4][5].
Manufacturer - Research Area
Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility
H2O : ≥ 125 mg/mL
Manufacturer - Pathway
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Isoform
Human Endogenous Metabolite; Microbial Metabolite
Clinical information
Phase 1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10mM/1mL
Lieferbar: In stock
lieferbar

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