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Sertaconazole (nitrate)

Sertaconazole (nitrate)

ArtNr	HY-B0736A-50mg
Hersteller	MedChem Express
CAS-Nr.	99592-39-9
Menge	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.58
Formula	C20H16Cl3N3O4S
Citations	[1]Carrillo-Muñoz AJ, et al. In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp. J Antimicrob Chemother. 1995 Oct;36(4):713-6.<br/>[2]Sur R, et al. Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway. J Invest Dermatol. 2008 Feb;128(2):336-44.<br/>[3]Sebastian J, et al. Sertaconazole induced toxicity in HeLa cells through mitotic arrest and inhibition of microtubule assembly. Naunyn Schmiedebergs Arch Pharmacol. 2021 Jun;394(6):1231-1249.<br/>[4]Zhang W, et al. Sertaconazole provokes proapoptotic autophagy via stabilizing TRADD in nonsmall cell lung cancer cells. MedComm (2020). 2021 Dec 16;2(4):821-837.
Smiles	ClC1=CC=C(C(OCC2=CSC3=C(Cl)C=CC=C32)CN4C=CN=C4)C(Cl)=C1.O[N+]([O-])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	FI7056
Lieferbar
Product Description	Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells[1][2][3][4].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	500.78
Clinical Information	Launched
Manufacturers Research Area	Infection
Solubility	DMSO : ≥ 100 mg/mL
Target	Apoptosis; Autophagy; Fungal; Microtubule/Tubulin; p38 MAPK
Manufacturers Target	Apoptosis; Autophagy; Fungal; Microtubule/Tubulin; p38 MAPK
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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HY-B0736A-50mg-safety-datasheet.pdf