ArtNr |
HY-B0735A-100mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
67227-57-0 |
Menge |
100 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
99.94 |
Formula |
C17H20ClNO6S |
Citations |
Cell. 2021 Feb 18;184(4):943-956.e18.<br/>Biochem Biophys Res Commun. 18 December 2021.<br/>Biomed Pharmacother. 2021, 111500.<br/>SLAS Discov. 2020 Sep;25(8):895-905.<br/>[1]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8.<br/>[2]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.<br/>[3]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602. |
Smiles |
OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Fenoldopam (methanesulfonate); SKF-82526 (mesylate) |
Lieferbar |
|
Product Description |
Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
401.86 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Cardiovascular Disease |
Solubility |
DMSO : ≥ 36 mg/mL|H2O : 10 mg/mL (ultrasonic) |
Target |
Apoptosis; Dopamine Receptor |
Manufacturers Target |
Apoptosis; Dopamine Receptor |
Manufacturers Pathway |
Apoptosis; GPCR/G Protein; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
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