ArtNr |
HY-B0263-5g |
Hersteller |
MedChem Express
|
CAS-Nr. |
148-79-8 |
Menge |
5 g |
Quantity options |
10mM/1mL
1 g
500 mg
5 g
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
99.88 |
Citations |
[1]Cha, H.J., et al., Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol, 2012. 10(8): p. e1001379. [2]Zhang, J., et al., Thiabendazole, a well-known antifungal drug, exhibits anti-metastatic melanoma B16F10 activity via inhibiting VEGF expression and inducing apoptosis. Pharmazie, 2013. 68(12): p. 962-8. [3]Budetić M, et al. Review of Characteristics and Analytical Methods for Determination of Thiabendazole. Molecules. 2023 May 6;28(9):3926. [4]Park J, et al. Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish. Environ Int. 2023 Jun;176:107973. [5]Elgebaly SA, et al. Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease. Am J Pathol. 1984 May;115(2):204-11. [6]Motwadie ME, et al. Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats. Int Immunopharmacol. 2021 Sep;98:107902. |
Smiles |
C1(C2=CSC=N2)=NC3=CC=CC=C3N1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Tiabendazole; 2-(4-Thiazolyl)benzimidazole |
Lieferbar |
|
Product Description |
Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling[1][2][3][4][5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
201.25 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease |
Solubility |
DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic) |
Target |
Caspase; CDK; Interleukin Related; MDM-2/p53; Mitochondrial Metabolism; Parasite; VEGFR |
Manufacturers Target |
Caspase; CDK; Interleukin Related; MDM-2/p53; Mitochondrial Metabolism; Parasite; VEGFR |
Isoform |
Caspase 3; Caspase 9; CDK1; CDK2; IL-1; IL-10; IL-13; IL-6 |
Manufacturers Pathway |
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK |
Manufacturers Product type |
Reference compound |
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