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Imiquimod (maleate)

Imiquimod (maleate)

ArtNr	HY-B0180B-500mg
Hersteller	MedChem Express
CAS-Nr.	896106-16-4
Menge	500 mg
Quantity options	100 mg 1 ea 200 mg 500 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.25
Formula	C18H20N4O4
Citations	Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.<br/>Pharmacol Res. 2023 Nov 24:198:107016.<br/>ACS Appl Bio Mater. 2019, 2, 874-883.<br/>Am J Respir Cell Mol Biol. 2022 Oct 13.<br/>Biochem Biophys Res Commun. 2024 Feb 15, 149661.<br/>Biomaterials. 2021, 120724.<br/>Biomaterials. 2022 Feb 14;282:121411.<br/>Cell Commun Signal. 2023 Aug 18;21(1):215.<br/>Cell Rep. 2021 Feb 2;34(5):108724.<br/>Diam Relat Mater. 2023 May 26, 110058.<br/>Drug Deliv. 2023 Dec;30(1):2183814.<br/>EMBO Rep. 2022 Feb 3;23(2):e53499.<br/>FEBS Lett. 2021 Aug 13.<br/>J Agric Food Chem. 2024 Jan 3.<br/>J Cell Mol Med. 2024 Apr;28(8):e18356.<br/>J Control Release. 2023 Aug 12;361:443-454.<br/>J Ethnopharmacol. 2024 Jan 2:117711.<br/>J Invest Dermatol. 2021 Oct 20;S0022-202X(21)02369-1.<br/>J Nanobiotechnology. 2022 May 14;20(1):228.<br/>MedComm. 04 March 2022.<br/>Nat Commun. 2016 May 25;7:11724. <br/>Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.<br/>Oxid Med Cell Longev. 12 Oct 2022.<br/>Research Square Preprint. 2021 Oct.<br/>Research Square Preprint. 2023 Nov 17.<br/>Research Square Print. 2023 Feb 1.<br/>Sci Rep. 2024 Mar 4;14(1):5237.<br/>Theranostics. 2023 Apr 9;13(7):2226-2240.<br/>bioRxiv. 2024 Apr 20.<br/>Int J Pharm. 2023 Nov 7:648:123583.<br/>J Nanobiotechnology. 2023 Feb 10;21(1):50.<br/>Nat Commun. 2022 Jul 22;13(1):4255.<br/>Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.<br/>protocols.io. 2024 Apr 13.<br/>Virulence. 2023 Dec;14(1):2223394.<br/>[1]Athina Angelopoulou, et al. Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858.<br/>[2]Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60.<br/>[3]Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46.<br/>[4]Michael P Schön, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47.
Smiles	NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C.O=C(O)/C=C\C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Imiquimod (maleate)
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Product Description	Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	356.38
Clinical Information	Launched
Manufacturers Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Autophagy; HSV; SARS-CoV; Toll-like Receptor (TLR)
Manufacturers Target	Autophagy; HSV; SARS-CoV; Toll-like Receptor (TLR)
Isoform	HSV-1; TLR7
Manufacturers Pathway	Anti-infection; Autophagy; Immunology/Inflammation
Manufacturers Product type	Reference compound

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