ArtNr |
HY-A0077-5g |
Hersteller |
MedChem Express
|
CAS-Nr. |
58-39-9 |
Menge |
5 g |
Quantity options |
10mM/1mL
1 g
500 mg
5 g
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
99.95 |
Formula |
C21H26ClN3OS |
Citations |
[1]Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32(8):1715-26.<br/>[2]Lei Tao, et al. Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo. Toxicol Lett. 2022 Jul 29;367:76-87. <br/>[3]Min-Jeong Heo, et al. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis. Int J Mol Sci. 2020 May 3;21(9):3241. <br/>[4]Michał Otręba, et al. Perphenazine and prochlorperazine decrease glioblastoma U-87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters, E-cadherin, α-tubulin and integrins (α3, α5, and β1) levels. Oncol Lett. 2022 Jun;23(6):182. <br/>[5]Michał Otręba, et al. n vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review. J Appl Toxicol. 2021 Jan;41(1):82-94. |
Smiles |
OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
58-39-9 |
Lieferbar |
|
Product Description |
Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation[1][3][5]. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
403.97 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ mg/mL |
Target |
5-HT Receptor; Adrenergic Receptor; Apoptosis; Autophagy; Dopamine Receptor; Histamine Receptor |
Manufacturers Target |
5-HT Receptor; Adrenergic Receptor; Apoptosis; Autophagy; Dopamine Receptor; Histamine Receptor |
Isoform |
5-HT1 Receptor; 5-HT2 Receptor; 5-HT6 Receptor; 5-HT7 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; H2 Receptor |
Manufacturers Pathway |
Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.