ArtNr |
HY-A0070-100mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
55-06-1 |
Menge |
100 mg |
Quantity options |
100 mg
10mM/1mL
500 mg
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
99.49 |
Formula |
C15H11I3NNaO4 |
Citations |
J Ethnopharmacol. 2022 Aug 11;115622.<br>JCI Insight. 2021 Jun 22;6(12):142838.<br>Sci Adv. 2024 Feb 9;10(6):eadk3931.<br>Acta Pharmacol Sin. 2024 May 24.<br>Adipocyte. 2022 Dec;11(1):84-98.<br>Am J Physiol Endocrinol Metab. 2024 Apr 3.<br>Cell Death Discov. 2022 Apr 30;8(1):236.<br>Cell Metab. 2023 Sep 7;S1550-4131(23)00304-2.<br>Cell Rep. 2024 Mar 18;43(3):113930.<br>Eur J Med Chem. 2024 Mar 20:269:116344.<br>Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.<br>J Med Chem. 2022 Jan 21.<br>J Nutr Biochem. 2020 Apr;78:108335.<br>Methods Mol Biol. 2023;2683:103-111.<br>Nat Commun. 2023 Jun 2;14(1):3208.<br>Patent. US20220389379A1.<br>[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.<br>[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.<br>[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. |
Smiles |
N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O |
ECLASS 5.1 |
30220300 |
ECLASS 6.1 |
30220300 |
ECLASS 8.0 |
32160605 |
ECLASS 9.0 |
32160605 |
ECLASS 10.0.1 |
32160490 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Triiodothyronine (sodium); 3,3',5-Triiodo-L-thyronine (sodium); T3 (sodium) |
Lieferbar |
|
Product Description |
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
672.96 |
Clinical_Information |
Launched |
Manufacturers Research Area |
Cancer; Endocrinology |
Solubility |
DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C) |
Manufacturers Target |
Endogenous Metabolite; Thyroid Hormone Receptor |
Isoform |
Human Endogenous Metabolite |
Pathway |
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor |
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