Palbociclib

ArtNr	HY-50767-10mg
Hersteller	MedChem Express
CAS-Nr.	571190-30-2
Menge	10 mg
Quantity options	100 mg 10 mg 1 g 200 mg 500 mg 50 mg 5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Breast Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.97
Formula	C24H29N7O2
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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. <br>[2]Goel S, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 Aug 24;548(7668):471-475. <br>[3]Richard S Finn, et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5):R77. <br>[4]Bollard J, et al. Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut. 2017 Jul;66(7):1286-1296.
Smiles	O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PD 0332991
Lieferbar
Product Description	Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	447.53
Clinical_Information	Launched
Manufacturers Research Area	Cancer
Solubility	0.1 M HCL : 25 mg/mL (ultrasonic; adjust pH to 4 with 0.1 M HCL)\|DMSO : 11.11 mg/mL (ultrasonic; warming; adjust pH to 4 with 1M HCl; heat to 60°C)\|H2O : < 0.1 mg/mL
Manufacturers Target	CDK
Isoform	CDK4; CDK6
Pathway	Cell Cycle/DNA Damage

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HY-50767-10mg-safety-datasheet.pdf