ArtNr |
HY-18731-5mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
214358-33-5 |
Menge |
5 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.94 |
Formula |
C10H17Cl2N3 |
Citations |
Biomed Pharmacother. 2022 Jul;151:113098.<br>Biomed Pharmacother. 2022 Sep;153:113532.<br>Cell Rep. 2022 Feb 15;38(7):110391.<br>Int J Biol Sci. 2020 Mar 5;16(9):1563-1574.<br>Int J Ophthalmol. 2022 Jul 18;15(7):1053-1061.<br>iScience. 2023 Jul 7.<br>J Transl Med. 2023 Nov 25;21(1):852.<br>Microvasc Res. 2022: 104468.<br>Mol Cell. 2020 Jan 2;77(1):95-107.e5. <br>Mucosal Immunol. 2024 Feb 20:S1933-0219(24)00015-1.<br>Redox Biol. 2023 Sep 27, 102905.<br>Sci Total Environ. 2020 Jan 1;698:134294.<br>Skelet Muscle. 2022 Jul 29;12(1):19.<br>ISME J. 2024 Jan 28:wrae014.<br>[1]Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63.<br>[2]Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199. |
Smiles |
CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
214358-33-5 |
Lieferbar |
|
Product Description |
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
250.17 |
Clinical_Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Inflammation/Immunology; Cardiovascular Disease |
Solubility |
DMSO : 20 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic) |
Manufacturers Target |
Apoptosis; NO Synthase |
Isoform |
iNOS |
Pathway |
Apoptosis; Immunology/Inflammation |
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