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L-NAME (hydrochloride)

L-NAME (hydrochloride)

ArtNr	HY-18729A-500mg
Hersteller	MedChem Express
CAS-Nr.	51298-62-5
Menge	500 mg
Quantity options	100 mg 10mM/1mL 500 mg
Kategorie	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.70
Formula	C7H16ClN5O4
Citations	Adv Sci (Weinh). 2024 Apr 3:e2309002.<br>Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1705-1721.<br>Bioengineered. 2022 Jan;13(1):1320-1334.<br>Biomed Pharmacother. 2019 Jul;115:108934. <br>Biomed Pharmacother. 2023 Mar 13;161:114484.<br>Biomed Res Int. 2021 May 15.<br>bioRxiv. 2023 Dec 4.<br>bioRxiv. 2023 Nov 1.<br>Bosn J Basic Med Sci. 2017 May 20;17(2):132-137.<br>Cancer Metab. 2024 May 17;12(1):14.<br>Cancer Res. 2024 Mar 19.<br>Cardiovasc Diabetol. 2024 May 9;23(1):164.<br>Cell Commun Signal. 2021 Mar 18;19(1):35.<br>Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641.<br>Exp Ther Med. 2018 Aug;16(2):1079-1086.<br>Front Cardiovasc Med. 2021 Apr 13;8:654254.<br>Front Med. 2021 Apr 13;8:634882.<br>Hum Gene Ther. 2022 Nov 14.<br>Insect Mol Biol. 2024 Jan 5.<br>Int Immunopharmacol. 2023 Dec 21:127:111313.<br>Int J Immunopathol Pharmacol. Jan-Dec 2022;36:3946320221111117.<br>Int J Mol Sci. 2023 Mar 7.<br>J Cell Mol Med. 2024 Apr;28(8):1-11.<br>J Ethnopharmacol. 2022 Jun 17;115476.<br>J Extracell Vesicles. 2023 May;12(5):e12328.<br>JCI Insight. 2021 Sep 22;6(18):e133690.<br>Mediat Inflamm. 2019 Oct 7;2019:6168340.<br>Mediat Inflamm. 2020 Oct 24;2020:1649453.<br>Microvasc Res. 2023 Mar 22;148:104531.<br>Mol Cell Probes. 2023 Feb 2;67:101896.<br>Nutrients. 2022, 14(23), 5025<br>PeerJ. 2023 May 25.<br>Phytomedicine. 6 June 2022, 154242.<br>Placenta. 12 November 2021.<br>Placenta. 2021 Feb 11.<br>Research Square Preprint. 2021 Feb.<br>Research Square Preprint. 2022 May.<br>Research Square Preprint. 2023 May 30.<br>Toxicol Appl Pharmacol. 2019 Mar 1;366:83-95. <br>Vet Microbiol. 19 July 2022, 109514.<br>Biomed Pharmacother. 2020 Aug;128:110240.<br>Cell Tissue Res. 2022 Jan 29.<br>[1]Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40.<br>[2]Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20.<br>[3]Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36.<br>[4]Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973.<br>[5]Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8.<br>[6]V A Peotta, et al. Cardiovascular neural reflexes in L-NAME-induced hypertension in mice. Hypertension. 2001, 38, 3.<br>[7]Xiaofei Li, et al. Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the l-NAME-induced hypertensive rat model. Food Funct. 2016, 7, 5.
Smiles	N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(OC)=O.[H]Cl
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NG-Nitroarginine methyl ester hydrochloride
Lieferbar
Product Description	L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	269.69
Clinical_Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	H2O : 100 mg/mL (ultrasonic)
Manufacturers Target	NO Synthase
Pathway	Immunology/Inflammation

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HY-18729A-500mg-safety-datasheet.pdf