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Losartan (potassium)

Losartan (potassium)

ArtNr	HY-17512A-500mg
Hersteller	MedChem Express
CAS-Nr.	124750-99-8
Menge	500 mg
Quantity options	10mM/1mL 1 g 500 mg 5 g
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.91
Formula	C22H22ClKN6O
Citations	Cell Death Dis. 2020 May 22;11(5):390.<br/>Chem Biol Interact. 2023 Jul 14;110636.<br/>FASEB J. 2019 May;33(5):6254-6268. <br/>Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592.<br/>Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F941-F953.<br/>Apoptosis. 2024 Jun 9.<br/>Arch Biol Sci. 2021 Jun.<br/>Biomolecules. 2022, 12(12), 1754.<br/>Biomolecules. 2023 Apr 25, 13(5), 740.<br/>Clin Sci. 2021 Mar 26;135(6):793-810.<br/>Clin Transl Med. 2023 Mar;13(3):e1213.<br/>FASEB J. 2018 Sep;32(9):5051-5062.<br/>Friedrich-Alexander University Erlangen-Nuremberg. 2023 May 2.<br/>Front Physiol. 2020 Sep 8;11:560170.<br/>Gene. 2022 Jan 31;146239.<br/>Int Immunopharmacol. 2023 Aug 4;123:110761.<br/>Int J Mol Sci. 2023 Feb 3;24(3):2960.<br/>Int J Nanomedicine. 2018 Nov 13;13:7409-7426. <br/>J Orthop Surg Res. 2024 Feb 19;19(1):147.<br/>J Pharmacol Sci. 2020 Sep;144(1):30-42.<br/>J Physiol. 2023 Dec 28.<br/>J Transl Med. 2024 Jan 5;22(1):26.<br/>Nefrologia. 2023 Sep 6.<br/>Oncogene. 2023 Feb 23.<br/>Oxid Med Cell Longev. 2022 Feb 18;2022:5044046.<br/>Phytomedicine. 2022 Mar 21;100:154067.<br/>Phytomedicine. 2023 Feb 4;112:154700.<br/>Rep Biochem Mol Biol. 2021 Jul;10(2):314-326.<br/>Reports of Biochemistry and Molecular Biology. 2021 Aug.<br/>Research Square Print. September 13th, 2022.<br/>Sci Rep. 2019 Dec 19;9(1):19450.<br/>Toxicol Appl Pharmacol. 2024 Apr 28:486:116945.<br/>[1]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.<br/>[2]Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.<br/>[3]Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31.<br/>[4]Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312(5770): p. 117-21.<br/>[5]Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26(2): p. 233-40.
Smiles	OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=N[N-]N=N4)C=C2.[K+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	DuP-753 (potassium)
Lieferbar
Product Description	Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	461.00
Clinical Information	Launched
Manufacturers Research Area	Cardiovascular Disease; Endocrinology; Cancer
Solubility	DMSO : ≥ 110 mg/mL\|H2O : 50 mg/mL (ultrasonic)
Target	Angiotensin Receptor
Manufacturers Target	Angiotensin Receptor
Isoform	AT1 Receptor
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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HY-17512A-500mg-safety-datasheet.pdf