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GSK-J4 (hydrochloride)

GSK-J4 (hydrochloride)

ArtNr	HY-15648F-50mg
Hersteller	MedChem Express
CAS-Nr.	1797983-09-5
Menge	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.83
Formula	C24H28ClN5O2
Citations	[1]Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8.<br/>[2]Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499.<br/>[3]Donas C, et al. The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. J Autoimmun. 2016 Dec;75:105-117.<br/>[4]Yapp C, et al. H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis. Arthritis Res Ther. 2016 Jul 7;18(1):158<br/>[5]Kamikawa YF, et al. Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. PLoS One. 2015 May 20;10(5):e0125626<br/>[6]Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2
Smiles	O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1797983-09-5
Lieferbar
Product Description	GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	453.96
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic)\|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 80°C)
Target	Histone Demethylase
Manufacturers Target	Histone Demethylase
Isoform	KDM6
Manufacturers Pathway	Epigenetics
Manufacturers Product type	Reference compound

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HY-15648F-50mg-safety-datasheet.pdf