Salinomycin

ArtNr	HY-15597-50mg
Hersteller	MedChem Express
CAS-Nr.	53003-10-4
Menge	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Antibiotics Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Breast Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	98.39
Formula	C42H70O11
Citations	ACS Infect Dis. 2021 Aug 13;7(8):2390-2401.<br/>Acta Biomater. 2022 Aug 23;S1742-7061(22)00501-3.<br/>Anal Chem. 2022 Sep 19.<br/>Biomed J. 2020 Aug;43(4):368-374.<br/>bioRxiv. 2020 Jun.<br/>bioRxiv. 2023 Jan 17.<br/>bioRxiv. 2023 Jun 25.<br/>Biosens Bioelectron. 2024 Jul 1:255:116245.<br/>Cancers. 2020 Aug 5;12(8):2176.<br/>Cell Biosci. 2021 Aug 4;11(1):156.<br/>Cell Commun Signal. 2018 Nov 23;16(1):89.<br/>Cell Death Dis. 2023 Mar 11;14(3):193.<br/>EMBO Mol Med. 2019 Oct;11(10):e9930.<br/>Int J Mol Med. 2019 Oct;44(4):1289-1298.<br/>Int J Mol Sci. 2019 Jun 12;20(12):2861.<br/>Int J Mol Sci. 2023 Mar 21;24(6):5939.<br/>Int J Nanomedicine. 2020 Sep 15;15:6839-6854.<br/>J Bioenerg Biomembr. 2021 Aug 8.<br/>J Control Release. 2020 Oct 10;326:387-395.<br/>Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct.<br/>Oncol Rep. 2018 Aug;40(2):877-886.<br/>Pharmacol Res. 2020 May;155:104751.<br/>RSC Adv. 2021 Nov 2;11(56):35331-35341.<br/>Viruses. 2022, 14(8), 1734.<br/>Exp Ther Med. 2020 Mar;19(3):1835-1843.<br/>Int J Pharm. 2023 Feb 24;122779.<br/>[1]Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.<br/>[2]Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.<br/>[3]Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638.<br/>[4]Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8(7):578-82.<br/>[5]Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14(2):e0211916.<br/>[6]Naujokat C, et al. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658.
Smiles	[H][C@]1([C@](C)(CC2)O[C@]32[C@H](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@H]4C)O3)CC[C@@](CC)(O)[C@H](C)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Procoxacin
Lieferbar
Product Description	Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	751.00
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 36.7 mg/mL
Target	Antibiotic; Apoptosis; Autophagy; Bacterial; Mitophagy; Parasite; Wnt; β-catenin
Manufacturers Target	Antibiotic; Apoptosis; Autophagy; Bacterial; Mitophagy; Parasite; Wnt; β-catenin
Isoform	Coccidia
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Stem Cell/Wnt
Manufacturers Product type	Reference compound

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

HY-15597-50mg-safety-datasheet.pdf