Salinomycin

ArtNr	HY-15597-50mg
Hersteller	MedChem Express
CAS-Nr.	53003-10-4
Menge	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Antibiotics Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Breast Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.66
Formula	C42H70O11
Citations	ACS Infect Dis. 2021 Aug 13;7(8):2390-2401. Acta Biomater. 2022 Aug 23;S1742-7061(22)00501-3. Adv Sci (Weinh). 2025 Feb 8:e2415229. Anal Chem. 2022 Sep 19. Biomed J. 2020 Aug;43(4):368-374. bioRxiv. 2020 Jun. bioRxiv. 2023 Jan 17. bioRxiv. 2023 Jun 25. bioRxiv. 2024 September 07. bioRxiv. 2024 September 18. Biosens Bioelectron. 2024 Jul 1:255:116245. Cancers. 2020 Aug 5;12(8):2176. Cell Biosci. 2021 Aug 4;11(1):156. Cell Commun Signal. 2018 Nov 23;16(1):89. Cell Death Dis. 2023 Mar 11;14(3):193. Cell Oncol (Dordr). 2024 Oct 7. Chemosphere. 2024 Jul 3:142758. EMBO Mol Med. 2019 Oct;11(10):e9930. Eur J Med Chem. 2024 Oct 5:276:116701. Eur J Pharmacol. 2025 Mar 20:177533. Int J Mol Med. 2019 Oct;44(4):1289-1298. Int J Mol Sci. 2019 Jun 12;20(12):2861. Int J Mol Sci. 2023 Mar 21;24(6):5939. Int J Nanomedicine. 2020 Sep 15;15:6839-6854. J Bioenerg Biomembr. 2021 Aug 8. J Control Release. 2020 Oct 10;326:387-395. Mol Med. 2025 Jan 22;31(1):19. Nanoscale. 2024 Oct 18. Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct. Oncol Rep. 2018 Aug;40(2):877-886. Pharmacol Res. 2020 May;155:104751. RSC Adv. 2021 Nov 2;11(56):35331-35341. Viruses. 2022, 14(8), 1734. AAPS PharmSciTech. 2024 Sep 7;25(7):211. Eur J Med Chem. 2024 Oct 5:276:116701. Exp Ther Med. 2020 Mar;19(3):1835-1843. Int J Pharm. 2023 Feb 24;122779. SSRN. 2024 Nov 12. [1]Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7. [2]Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45. [3]Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638. [4]Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8(7):578-82. [5]Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14(2):e0211916. [6]Naujokat C, et al. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658.
Smiles	[H][C@]1([C@](C)(CC2)O[C@]32[C@H](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@H]4C)O3)CC[C@@](CC)(O)[C@H](C)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Procoxacin
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Antibiotic; Apoptosis; Autophagy; Bacterial; Mitophagy; Parasite; Wnt; β-catenin
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	751.00
Product Description	Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 36.7 mg/mL
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; Stem Cell/Wnt
Isoform	Coccidia
Clinical information	No Development Reported

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

HY-15597-50mg-safety-datasheet.pdf