ArtNr |
HY-15584A-50mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
228266-41-9 |
Menge |
50mg |
Quantity options |
10mM/1mL
10 mg
50mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.08 |
Citations |
[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. |
Smiles |
CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\C)C)=O.O=C(O)C(F)(F)F |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
HTI-286 trifluoroacetate; SPA-110 trifluoroacetate |
Lieferbar |
|
Product Description |
Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
587.67 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : ≥ 39 mg/mL |
Target |
ADC Cytotoxin; Apoptosis; Microtubule/Tubulin |
Manufacturers Target |
ADC Cytotoxin; Apoptosis; Microtubule/Tubulin |
Isoform |
Traditional Cytotoxic Agents |
Manufacturers Pathway |
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton |
Manufacturers Product type |
ADC Related |
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