Zardaverine

ArtNr	HY-15485-50mg
Hersteller	MedChem Express
CAS-Nr.	101975-10-4
Menge	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Food Safety Drugs Neuroscience Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Hypertension Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.73
Formula	C12H10F2N2O3
Citations	[1]Kips JC, et al. The effect of zardaverine, an inhibitor of phosphodiesterase isoenzymes III and IV, on endotoxin-induced airway changes in rats. Clin Exp Allergy. 1993 Jun;23(6):518-23. <br>[2]Schudt C, et al. Zardaverine: a cyclic AMP specific PDE III/IV inhibitor. Agents Actions Suppl. 1991;34:379-402. <br>[3]Sun L, et al. Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition. PLoS One. 2014 Mar 5;9(3):e90627.
Smiles	O=C1C=CC(C2=CC=C(OC(F)F)C(OC)=C2)=NN1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	101975-10-4
Lieferbar
Product Description	Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	268.22
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Phosphodiesterase (PDE)
Isoform	PDE3; PDE4
Pathway	Apoptosis; Metabolic Enzyme/Protease

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