YS-49

ArtNr	HY-15477-10mg
Hersteller	MedChem Express
CAS-Nr.	132836-42-1
Menge	10 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.92
Formula	C20H20BrNO2
Citations	[1]Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.<br/>[2]Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64.<br/>[3]Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65.
Smiles	OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	132836-42-1
Lieferbar
Product Description	YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors[1][2][3].
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	386.28
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease; Endocrinology
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K
Manufacturers Target	Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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HY-15477-10mg-safety-datasheet.pdf