XAV-939

ArtNr	HY-15147-100mg
Hersteller	MedChem Express
CAS-Nr.	284028-89-3
Menge	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Kategorie	Neuroscience Molecular Targets for Neuroscience Cardiovascular Research Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.91
Formula	C14H11F3N2OS
Citations	[1]Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9.<br/>[2]Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10(1):16746. <br/>[3]Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445.
Smiles	O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	284028-89-3
Lieferbar
Product Description	XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	312.31
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : ≥ mg/mL
Target	PARP; β-catenin
Manufacturers Target	PARP; β-catenin
Isoform	PARP1; PARP2; TNKS1/PARP5A; TNKS2/PARP5B
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-15147-100mg-safety-datasheet.pdf