ArtNr |
HY-15036A-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
78213-16-8 |
Menge |
10mM/1mL |
Quantity options |
10 g
10mM/1mL
500 mg
5 g
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.96 |
Formula |
C18H22Cl2N2O2 |
Citations |
Pharm Res. 2022 Aug 24.<br/>Arch Microbiol. 2024 Jun 7;206(7):289.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. <br/>Toxicol Mech Methods. 2019 Nov;29(9):654-664.<br/>bioRxiv. 2024 Apr 7.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>Chem-Biol Interact. 2021, 109425.<br/>Chemosphere. 2019 Jun;225:378-387. <br/>Eur J Drug Metab Pharmacokinet. 2022 Jun 22.<br/>Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov.<br/>Int J Mol Sci. 2022, 23(20), 12066.<br/>J Hazard Mater. 2015 May 30;289:18-27.<br/>J Pharmaceut Biomed. 2021, 114105.<br/>J Phys Chem Solids. 2017 October;109:117-123.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.<br/>[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.<br/>[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. |
Smiles |
O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl.CCNCC |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
78213-16-8 |
Lieferbar |
|
Product Description |
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
369.29 |
Clinical Information |
Launched |
Manufacturers Research Area |
Inflammation/Immunology; Cancer |
Solubility |
DMSO : 150 mg/mL (ultrasonic) |
Target |
Apoptosis; COX |
Manufacturers Target |
Apoptosis; COX |
Isoform |
COX-1; COX-2 |
Manufacturers Pathway |
Apoptosis; Immunology/Inflammation |
Manufacturers Product type |
Reference compound |
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