Prinaberel

ArtNr	HY-14933-50mg
Hersteller	MedChem Express
CAS-Nr.	524684-52-4
Menge	50 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	98.05
Formula	C15H10FNO3
Citations	[1]Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040.<br/>[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.<br/>[3]Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018 May 1.
Smiles	OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ERB-041
Lieferbar
Product Description	Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	271.24
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 40 mg/mL
Target	Apoptosis; Estrogen Receptor/ERR; Wnt
Manufacturers Target	Apoptosis; Estrogen Receptor/ERR; Wnt
Isoform	ERα; ERβ
Manufacturers Pathway	Apoptosis; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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HY-14933-50mg-safety-datasheet.pdf