ArtNr |
HY-14914-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
147403-03-0 |
Menge |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
99.51 |
Formula |
C25H20N4O5 |
Citations |
[1]Kajiya T, et al. Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.<br/>[2]Zhao M, et al. Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes Obes Metab. 2011 Dec;13(12):1123-9.<br/>[3]Ojima M, et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011 Mar;336(3):801-8. <br/>[4]Gupta V, et al. Neuroprotective potential of azilsartan against cerebral ischemic injury: Possible involvement of mitochondrial mechanisms. Neurochem Int. 2020 Jan;132:104604.<br/>[5]Ahmadian E, et al. Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2. Biomed Pharmacother. 2018 Mar;99:939-946. |
Smiles |
O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C(N5)=NOC5=O)C=C3)=CC=C1)O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
TAK-536 |
Lieferbar |
|
Product Description |
Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[1][2][3][4][5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
456.45 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease |
Solubility |
DMSO : 25 mg/mL (ultrasonic) |
Target |
Angiotensin Receptor; Apoptosis; Reactive Oxygen Species |
Manufacturers Target |
Angiotensin Receptor; Apoptosis; Reactive Oxygen Species |
Isoform |
AT1 Receptor |
Manufacturers Pathway |
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB |
Manufacturers Product type |
Reference compound |
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