Epoxomicin

ArtNr	HY-13821-1mg
Hersteller	MedChem Express
CAS-Nr.	134381-21-8
Menge	1 mg
Quantity options	100 ug 10mM/1mL 10 mg 1 mg 20 mg 5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Typ	Inhibitors
Specific against	other
Purity	99.69
Formula	C28H50N4O7
Citations	[1]Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.<br/>[2]Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.<br/>[3]Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82.<br/>[4]McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62.<br/>[5]Meng L, et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10403-8.
Smiles	O=C([C@@H](NC([C@H]([C@@H](C)O)NC([C@@H](NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)[C@@]1(C)CO1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BU-4061T
Lieferbar
Product Description	Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity[1][2][3][4][5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	554.72
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Apoptosis; Proteasome
Manufacturers Target	Apoptosis; Proteasome
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-13821-1mg-safety-datasheet.pdf