Tacrolimus

ArtNr	HY-13756-50mg
Hersteller	MedChem Express
CAS-Nr.	104987-11-3
Menge	50 mg
Quantity options	100 mg 10 mg 200 mg 500 mg 50 mg 5 mg
Kategorie	Food Safety Drugs Histamines Hormones Neuroscience Metabolism Cholesterol & Lipid Metabolism Neural Signaling Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.93
Formula	C44H69NO12
Citations	Acs Biomater Sci Eng. 2022 Oct 10. Acta Pharmacol Sin. 2024 May 17. Acta Trop. 2020 Dec;212:105708. Adv Funct Mater. 2023 Sep 15. Aging Dis. 2023 Jun 6. Am J Digest Dis. 2015;2(2):95-99. Am J Transplant. 2022. Animal Model Exp Med. 2022 Sep 21. Antiviral Res. 2023 May 2;105618. Biochim Biophys Acta Gen Subj. 2022 Jun;1866(6):130133. Biomater Sci. 2020 Oct 7;8(19):5282-5292. Biomater Sci. 2023 May 2. Biomaterials. 2021, 120757. Biomolecules. 2024 Jun 08. BMC Immunol. 2023 Nov 8;24(1):43. BMC Pharmacol Toxicol. 2022 Nov 28;23(1):87. Br J Pharmacol. 2022 Jan 20. Brain Res. 2019 May 15;1711:68-76. Cancer Lett. 2024 Apr 11:216841. Cell Biol Toxicol. 2022 Jun;38(3):487-504. Cell Commun Signal. 2021 Oct 11;19(1):103. Cell Mol Biol Lett. 2024 May 14;29(1):72. Cell Prolif. 2023 Mar 27;e13460. Cell Rep. 2021 Jul 20;36(3):109404. Cell Syst. 2018 Apr 25;6(4):424-443.e7. Dis Model Mech. 2019 Jan 28;12(1). pii: dmm036830. Drug Deliv. 2021 Dec;28(1):1759-1768. Elife. 2023 MAy 19. Exp Hematol Oncol. 2016 Jul 29;5:22. FASEB J. 2023 Feb;37(2):e22749. Food Funct. 2023 Jul 3. Hepatobiliary Pancreat Dis Int. 2023 Aug 22. Hepatobiliary Surg Nutr. 2023 Feb 27. Hong Kong Polytechnic University. 2023 Apr. Insect Sci. 2023 Oct 12. Int J Biol Macromol. 2024 Aug 3:134478. Int J Biol Sci. 2024 Oct 7;20(14):5415-5435. Int J Mol Sci. 2022 Aug 19;23(16):9376. Int J Mol Sci. 2024 Feb 21, 25(5), 2503. Int J Pharm. 2019 Dec 13;575:118951. Int J Physiol Pathophysiol Pharmacol. 2015 Mar 20;7(1):54-60. Invest Ophthalmol Vis Sci. 2023 Jan 3;64(1):19. J Cell Sci. 2019 May 20;132(10):jcs227777. J Colloid Interface Sci. 5 October 2022. J Control Release. 2020 Dec 10;328:237-250. J Extracell Vesicles. 2019 Dec 27;9(1):1709262. J Neurochem. 2022 Oct 21. J Pharm Biomed Anal. 2023 Aug 19, 115652. J Toxicol Sci. 2024;49(8):337-348. J Vet Med Sci. 2023 Feb 17. Mater Design. 2023 Nov, 235, 112415. Mater Today Bio. 2024 Apr 22:101061. Mediat Inflamm. 2019 Dec 17;2019:4176974. Mol Med Rep. 2022 May;25(5):160. Nano Lett. 2019 Jan 9;19(1):124-134. Nano Res. 11, 6086-6101(2018). NPJ Regen Med. 2022 Sep 2;7(1):43. Patent. US20180263995A1. Patent. US20220087984A1. Pharmacol Res. 2021, 105382. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2009539118. Res Sq. 2024 Aug 13:rs.3.rs-4656461. Research Square Preprint. 2020 Dec. Signal Transduct Target Ther. 2023 Nov 1;8(1):417. Skelet Muscle. 2020 Apr 22;10(1):10. Theranostics. 2018 Jan 1;8(4):878-893. Theranostics. 2020 May 16;10(14):6483-6499. Theranostics. 2021 Mar 5;11(10):5045-5060. Theranostics. 2022 Jan 16;12(4):1621-1638. Toxins (Basel). 2019 Jun 18;11(6):349. Transpl Immunol. 2021 Jun 30;101434. Ultrasound Med Biol. 2023 Apr 27;S0301-5629(23)00108-4. Wound Repair Regen. 2023 May 2. Fundamental Research. 2024 Mar 19. SSRN. 2023 Oct 31. Toxics. 2024 Aug 19;12(8):607. Vaccines. 2024 Sep 29;12(10):1117. [1]Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91. [2]Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886. [3]Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92. [4]Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7. [5]Yuwei He, et al. Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis. Nano Res. 30 June 2018.
Smiles	O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	FK506, Fujimycin, FR900506
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Autophagy; Bacterial; FKBP; Phosphatase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	804.02
Product Description	Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : ≥ 150 mg/mL
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease
Isoform	Macrolide
Clinical information	Launched

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HY-13756-50mg-safety-datasheet.pdf