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Diminazene (aceturate)

Diminazene (aceturate)

ArtNr	HY-12404-10mM
Hersteller	MedChem Express
CAS-Nr.	908-54-3
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.16
Formula	C22H29N9O6
Citations	Cell Metab. 2022 Feb 7;34(3):424-440.e7.<br/>Endocrine. 2021 Mar 30;1-9.<br/>J Inflamm Res. 2023 Apr 17;16:1639-1652.<br/>Radiat Res. 2022 Jul 29.<br/>Research Square Preprint. 2021 Mar.<br/>J Inflamm Res. 2023 Apr 17;16:1639-1652.<br/>[1]Kuriakose S, et al. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS One. 2012;7(11):e48696.<br/>[2]Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21(2):342-5.<br/>[3]Castardeli C, et al. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218.
Smiles	O=C(O)CNC(C)=O.N=C(C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(O)CNC(C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Diminazene (diaceturate)
Lieferbar
Product Description	Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	515.52
Clinical Information	Launched
Manufacturers Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic)\|H2O : 50 mg/mL (ultrasonic)
Target	Angiotensin-converting Enzyme (ACE); Parasite
Manufacturers Target	Angiotensin-converting Enzyme (ACE); Parasite
Isoform	Trypanosoma
Manufacturers Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-12404-10mM-safety-datasheet.pdf