Aliskiren

ArtNr	HY-12176-10mM
Hersteller	MedChem Express
CAS-Nr.	173334-57-1
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.24
Formula	C30H53N3O6
Citations	Department of Biological Science. National Sun Yat-Sen University. 2015 Sep.<br/>Front Biosci-Landmrk. 2023 Oct 17, 28(10), 238.<br/>Lipids Health Dis. 2018 Jul 31;17(1):183. <br/>Neurobiol Dis. 2014 Nov;71:292-304. <br/>Department of Pharmaceutical Sciences. East Tennessee State University. 2015 May.<br/>Drug Metab Pharmacokinet. 2024 Mar 11, 101008.<br/>Toxicology Research and Application. September 25, 2018.<br/>Toxicology Research and Application. 2018, 2:239784731880115. <br/>[1]Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758<br/>[2]Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.<br/>[3]Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705.<br/>[4]Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018.<br/>[5]Chang AY, et al. Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke. Neurobiol Dis. 2014 Nov;71:292-304.<br/>[6]Wang C, et al. Aliskiren targets multiple systems to alleviate cancer cachexia. Oncol Rep. 2016 Nov;36(5):3014-3022.
Smiles	COCCCOC1=CC(C[C@@H](C[C@@H]([C@H](C[C@H](C(NCC(C)(C(N)=O)C)=O)C(C)C)O)N)C(C)C)=CC=C1OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CGP 60536; CGP60536B; SPP 100
Lieferbar
Product Description	Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	551.76
Clinical Information	Launched
Manufacturers Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 100 mg/mL (ultrasonic)
Target	Autophagy; Renin
Manufacturers Target	Autophagy; Renin
Manufacturers Pathway	Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

HY-12176-10mM-safety-datasheet.pdf