ArtNr |
HY-12170-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
192329-42-3 |
Menge |
10 mg |
Quantity options |
10mM*1 mL
10 mg
1 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.27 |
Formula |
C18H21N3O5S2 |
Citations |
Sci Adv. 2023 Jan 20;9(3):eadd3867.<br/>J Neuropathol Exp Neurol. 2022 Jun 3;nlac041.<br/>[1]Sørensen MD, et al. Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity. Bioorg Med Chem. 2003 Dec 1;11(24):5461-84.<br/>[2]Blavier L, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010 Jul 15;10(2):198-208.<br/>[3]Shalinsky DR, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci. 1999 Jun 30;878:236-70.<br/>[4]Ozerdem U, et al. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy. Curr Eye Res. 2000 Jun;20(6):447-53. |
Smiles |
O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
AG3340; KB-R9896 |
Similar products |
AG3340, KB-R9896 |
Lieferbar |
|
Product Description |
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3, MMP-13 and MMP-9 with Kis of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity[1][2][3][4]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
423.51 |
Clinical Information |
Phase 3 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : 2.5 mg/mL (ultrasonic; adjust pH to 4 with 1M HCl)|H2O : 2.5 mg/mL (ultrasonic; adjust pH to 3 with HCl) |
Target |
Apoptosis; MMP |
Manufacturers Target |
Apoptosis; MMP |
Isoform |
MMP-1; MMP-13; MMP-2; MMP-3; MMP-9 |
Manufacturers Pathway |
Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Reference compound |
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