SB 525334

ArtNr	HY-12043-10mM
Hersteller	MedChem Express
CAS-Nr.	356559-20-1
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Proteins Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Colorectal Cancer Neurodegeneration Markers;Research Area Oncology By Organ Breast Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.97
Formula	C21H21N5
Citations	[1]Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313(3), 943-951.<br>[2]Thomas M, et al. ALK5 mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol, 2009, 174(2), 380-389.<br>[3]Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13(10), 3087-3899.
Smiles	CC(C)(C1=NC(C2=CC=CC(C)=N2)=C(C3=CC=C4N=CC=NC4=C3)N1)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	356559-20-1
Lieferbar
Product Description	SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	343.42
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturers Target	TGF-β Receptor
Pathway	TGF-beta/Smad

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

HY-12043-10mM-safety-datasheet.pdf