ArtNr |
HY-12037A-50mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
592542-59-1 |
Menge |
50 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.35 |
Formula |
C21H25NO8S |
Citations |
Harvard Medical School LINCS LIBRARY<br/>Int J Biol Sci. 2020 Jun 27;16(13):2382-2391.<br/>Oncol Res. 2021 Feb 11.<br/>Sci Rep. 2017 Aug 17;7(1):8629. <br/>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br/>Harvard Medical School LINCS LIBRARY<br/>[1]Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.<br/>[2]Hyoda T, et al. Rigosertib induces cell death of a myelodysplastic syndrome-derived cell line by DNA damage-induced G2/M arrest. Cancer Sci. 2015 Mar;106(3):287-93.<br/>[3]Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86.<br/>[4]Reddy MV, et al. Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem. 2011 Sep 22;54(18):6254-76.<br/>[5]Chapman CM, et al. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91 |
Smiles |
COC1=CC=C(C=C1NCC(O)=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
ON-01910 |
Lieferbar |
|
Product Description |
Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3]. |
StorageTemperature |
-20°C (Powder, stored under nitrogen) |
Shipping |
Blue Ice |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
451.49 |
Clinical Information |
Phase 3 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : 75 mg/mL (ultrasonic) |
Target |
Apoptosis; PI3K; Polo-like Kinase (PLK) |
Manufacturers Target |
Apoptosis; PI3K; Polo-like Kinase (PLK) |
Isoform |
PLK1; PLK2 |
Manufacturers Pathway |
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR |
Manufacturers Product type |
Reference compound |
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