SB-431542

ArtNr	HY-10431-10mM
Hersteller	MedChem Express
CAS-Nr.	301836-41-9
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Drugs Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Neurodegeneration Markers;Research Area Oncology By Organ Breast Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.89
Formula	C22H16N4O3
Citations	[1]Gareth J Inman, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002 Jul;62(1):65-74.<br>[2]Sunil K Halder, et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005 May;7(5):509-21.<br>[3]Yi-qin Xiao, et al. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1698-706.
Smiles	O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	301836-41-9
Lieferbar
Product Description	SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	384.39
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : 11.17 mg/mL (ultrasonic; warming)
Manufacturers Target	Apoptosis; Organoid; TGF-β Receptor
Isoform	ALK4; ALK5; ALK7
Pathway	Apoptosis; Stem Cell/Wnt; TGF-beta/Smad

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HY-10431-10mM-safety-datasheet.pdf