ArtNr |
HY-10182-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
252917-06-9 |
Menge |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
200 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
99.76 |
Formula |
C22H18Cl2N8 |
Citations |
Biochemistry and Cell Biology. 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US20180263995A1.<br/>Patent. US20210002607A1.<br/>Pigment Cell Melanoma Res. 2023 Aug 9.<br/>PLoS Biol. 2019 Oct 15;17(10):e3000498.<br/>Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4989-4998.<br/>Programa de Doctorado en Biomedicina. 2020 Sep.<br/>Res Sq. 2024 Jun 03.<br/>Res Sq. 2024 May 20.<br/>Research Square Preprint. 2021 Feb.<br/>Research Square Preprint. 2021 Nov.<br/>Respir Res. 2022 Mar 25;23(1):70.<br/>Rice University, Department of Biological Sciences. 2020 Apr.<br/>Ruperto Carola University Heidelberg. Faculty of Natural Sciences and Mathematics. 03 Mar 2022.<br/>Sci Adv. 2021 Apr 14;7(16):eabb2213.<br/>Sci Adv. 2023 Dec 22;9(51):eadi5683.<br/>Sci China Life Sci. 2018 Oct;61(10):1151-1167.<br/>Sci Rep. 2019 Dec 10;9(1):18731. <br/>Small. 2020 Jun;16(22):e2001371.<br/>SSRN. 2023 Sep 1.<br/>STAR Protoc. 17 June 2022, 101426.<br/>STAR Protoc. 2021 Nov 5;2(4):100881.<br/>STAR Protoc. 2023 Feb 3;4(1):102092.<br/>STAR Protoc. 2023 Mar 16;4(2):102151.<br/>Stem Cell Res Ther. 2021 Mar 29;12(1):214.<br/>Stem Cell Res Ther. 2022 Feb 2;13(1):48.<br/>Stem Cell Res Ther. 2023 Jan 5;14(1):1.<br/>Stem Cell Res Ther. 2020 Apr 16;11(1):157.<br/>Stem Cells Int. 2018 Dec 25;2018:5965727.<br/>Stem Cells Int. 2020 Feb 3;2020:8483035.<br/>Stem Cells Transl Med. 2021 May;10(5):743-755.<br/>Stem Cells. 2019 Apr;37(4):489-503.<br/>Stem Cells. 2022 Jul 28;sxac050.<br/>Theranostics. 2018 Jul 30;8(15):4262-4278.<br/>Theranostics. 2019 Aug 12;9(20):5769-5783.<br/>Toxicol Appl Pharmacol. 2020 Jan 1;386:114813.<br/>Toxicology. 2016 May 20;355-356:31-38. <br/>Toxicology. 2020 Apr 15;435:152422.<br/>Toxins. 2021 Aug 22;13(8):585.<br/>University of Otago. Biomedical Sciences. 2021 Nov.<br/>UNIVERSITY OF PAVIA. 2023 Jul 9.<br/>Zool Res. 2021 May 18;42(3):377-388.<br/>EMBO Mol Med. 2022 Nov 2;e16194.<br/>J Transl Med. 2021 Oct 9;19(1):417.<br/>Poult Sci. 8 March 2022, 101825.<br/>[1]Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.<br/>[2]Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004.<br/>[3]Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273.<br/>[4]Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566.<br/>[5]Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7(4):e35892. |
Smiles |
N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
CHIR-99021; CT99021 |
Lieferbar |
|
Product Description |
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
465.34 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Metabolic Disease |
Solubility |
DMSO : 16.67 mg/mL (ultrasonic) |
Target |
Autophagy; GSK-3; Organoid; Wnt; β-catenin |
Manufacturers Target |
Autophagy; GSK-3; Organoid; Wnt; β-catenin |
Isoform |
GSK-3α; GSK-3β |
Manufacturers Pathway |
Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt |
Manufacturers Product type |
Reference compound |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.