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NPS-2143 (hydrochloride)

NPS-2143 (hydrochloride)

ArtNr	HY-10171-5mg
Hersteller	MedChem Express
CAS-Nr.	324523-20-8
Menge	5 mg
Quantity options	10mM/1mL 10 mg 1 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Hormones Neuroscience Metabolism Regulation of Appetite Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.80
Formula	C24H26Cl2N2O2
Citations	[1]Huang Y, Breitwieser GE. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J Biol Chem. 2007 Mar 30;282(13):9517-25<br/>[2]Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.;Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues. Journal of Medicinal Chemistry (2009), 52(21), 6599-6605.<br/>[3]Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX.Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension.Circ Res. 2012 Aug 3;111(4):469-81. Epub 2012 Jun 22.<br/>[4]Nakajima S, Hira T, Hara H.Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.Mol Nutr Food Res. 2012 May;56(5):753-60.<br/>[5]Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.Endocrinology. 2012 Mar;153(3):1232-41. Epub 2011 Dec 30.<br/>[6]Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.
Smiles	N#CC1=C(OC[C@@H](CNC(C)(C)CC2=CC=C3C=CC=CC3=C2)O)C=CC=C1Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SB-262470A (hydrochloride)
Lieferbar
Product Description	NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	445.38
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 1.85 mg/mL (ultrasonic; warming; heat to 60°C)
Target	CaSR
Manufacturers Target	CaSR
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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HY-10171-5mg-safety-datasheet.pdf