YM-58483

ArtNr	HY-100831-2mg
Hersteller	MedChem Express
CAS-Nr.	223499-30-7
Menge	2 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 2 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Allergenes Histamines Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Microglia Markers
Typ	Inhibitors
Specific against	other
Purity	99.78
Formula	C15H9F6N5OS
Citations	[1]Qi Z, et al. The Central Analgesic Mechanism of YM-58483 in Attenuating Neuropathic Pain in Rats. Cell Mol Neurobiol. 2016 Oct;36(7):1035-43<br/>[2]Ohga K, et al. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo. Int Immunopharmacol. 2008 Dec 20;8(13-14):1787-9<br/>[3]Ohga K, et al. The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo. Pulm Pharmacol Ther. 2008;21(2):360-9<br/>[4]Yoshino T, et al. YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33
Smiles	O=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BTP2
Lieferbar
Product Description	YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals[1]. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE)[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	421.32
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 125 mg/mL (ultrasonic)
Target	CRAC Channel
Manufacturers Target	CRAC Channel
Manufacturers Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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HY-100831-2mg-safety-datasheet.pdf