Urolithin A

ArtNr	HY-100599-10mM
Hersteller	MedChem Express
CAS-Nr.	1143-70-0
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Testicular & Prostate Cancer
Typ	Inhibitors
Specific against	other
Purity	99.82
Formula	C13H8O4
Citations	[1]Gong Z, et al. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.<br/>[2]Zhao W, et al. Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620colorectal cancer cells. Mol Carcinog. 2018 Feb;57(2):193-200.<br/>[3]Qiu Z, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013 Sep;59:428-37.<br/>[4]González-Sarrías A, et al. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.Eur J Nutr. 2017 Mar;56(2):831-841.<br/>[5]Wang Y, et al. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15.<br/>[6]Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.
Smiles	O=C1C2=CC(O)=CC=C2C3=CC=C(O)C=C3O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1143-70-0
Lieferbar
Product Description	Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	228.20
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : 30 mg/mL (ultrasonic)
Target	Apoptosis; Autophagy; DNA/RNA Synthesis; Drug Metabolite; Endogenous Metabolite; Reactive Oxygen Species
Manufacturers Target	Apoptosis; Autophagy; DNA/RNA Synthesis; Drug Metabolite; Endogenous Metabolite; Reactive Oxygen Species
Isoform	Microbial Metabolite
Manufacturers Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Manufacturers Product type	Natural Products

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