Product Description |
Nicastrin Protein, a crucial gamma-secretase complex subunit, catalyzes intramembrane cleavage of Notch receptors and APP. Operating in Notch and Wnt signaling, the complex modulates regulatory proteins and CTNNB1 levels. Collaborating with PSEN1/2, APH1A/B, and PSENEN/PEN2, Nicastrin binds to proteolytically processed C83 and C99 fragments, emphasizing its pivotal role in molecular pathways and cellular processes. Nicastrin Protein, Human (HEK293, His) is the recombinant human-derived Nicastrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Nicastrin Protein, Human (HEK293, His) is 636 a.a., with molecular weight of 110-120 kDa. |