Glypican-3/GPC3, Rhesus Macaque (HEK293, His)

GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. Membrane GPC3 can interact with several growth factors to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth. In addition, GPC3 is also involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome, regulates cell growth, regulates embryonic and fetal development[1][2][3]. Glypican-3/GPC3 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Rhesus Macaque (HEK293, His) is 535 a.a., with molecular weight of 38 & 65-120 kDa, respectively.

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Recombinant Proteins