MLKL Protein, Human (P.pastoris, His)

MLKL Protein, a pseudokinase, is pivotal in TNF-induced necroptosis. Despite lacking intrinsic kinase activity, it activates through RIPK3 phosphorylation, leading to homotrimerization, plasma membrane localization, and necroptosis execution. In orthomyxovirus infection, MLKL triggers nuclear necroptosis via ZBP1 activation, disrupting the nuclear envelope. Binding to highly phosphorylated inositol phosphates, like inositolhexakisphosphate (InsP6), mediates MLKL's necroptotic function, requiring RIPK3-dependent phosphorylation. Necrosulfonamide, a necroptosis inhibitor, targets Cys-86, effectively inhibiting MLKL function. MLKL Protein, Human (P.pastoris, His) is the recombinant human-derived MLKL protein, expressed by P. pastoris, with N-His labeled tag. The total length of MLKL Protein, Human (P.pastoris, His) is 471 a.a., with molecular weight of ~56.5 kDa.

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Recombinant Proteins