ArtNr |
HY-P3507A-1mg |
Hersteller |
MedChem Express
|
Menge |
1 mg |
Quantity options |
10 mg
1 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitor |
Specific against |
other |
Purity |
99.17 |
Formula |
C186H297F3N57O57PS7 |
Citations |
[1]Olsen C, et al. Dalazatide (ShK-186), a first-in-class peptide inhibitor of Kv1. 3 potassium channels, demonstrates safety, tolerability and proof of concept of efficacy in patients with active plaque psoriasis. J. Invest. Dermatol., 2016, 136(8).<br/>[2]Stevens A M, et al. Thu0285 Dalazatide, an Inhibitor of the KV1. 3 Channel on Activated Effector Memory T Cells, Has Immunotherapy Potential in Systemic Lupus Erythematosus. 2016.<br/>[3]Matheu MP, et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17;29(4):602-14. |
Smiles |
[Dalazatide (TFA salt)] |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
ShK-186 (TFA) |
Lieferbar |
|
Product Description |
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease[1][2][3]. |
StorageTemperature |
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture) |
Shipping |
Blue Ice |
Manufacturers Applications |
Metabolism-protein/nucleotide metabolism |
MolecularWeight |
4442.08 (free acid) |
Clinical Information |
Phase 1 |
Manufacturers Research Area |
Metabolic Disease; Inflammation/Immunology |
Solubility |
H2O : 100 mg/mL (ultrasonic) |
Target |
Potassium Channel |
Manufacturers Target |
Potassium Channel |
Manufacturers Pathway |
Membrane Transporter/Ion Channel |
Manufacturers Product type |
Peptides |
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