ArtNr |
HY-P2141-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
1234510-46-3 |
Menge |
10 mg |
Quantity options |
100 mg
10 mg
1 ea
1 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.46 |
Formula |
C43H67N13O10 |
Citations |
Eur J Pharmacol. 2023 May 18;175780.<br/>J Am Heart Assoc. 2022 Feb 15;11(4):e022070.<br/>University of Medicine Berlin. 2023 Mar.<br/>[1]Boerrigter G, et al. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.Circ Heart Fail. 2012 Sep 1;5(5):627-34. Epub 2012 Aug 13.<br/>[2]Liu CH, et al. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Nat Commun. 2017 Feb 9;8:14335. |
Smiles |
C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)CCC1)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling[1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment[2]. |
StorageTemperature |
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen) |
Shipping |
Blue Ice |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
926.07 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Cardiovascular Disease |
Solubility |
H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C) |
Target |
Angiotensin Receptor; Arrestin |
Manufacturers Target |
Angiotensin Receptor; Arrestin |
Isoform |
AT1 Receptor |
Manufacturers Pathway |
GPCR/G Protein |
Manufacturers Product type |
Peptides |
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