Dynorphin A

ArtNr	HY-P1333-1mg
Hersteller	MedChem Express
CAS-Nr.	80448-90-4
Menge	1 mg
Quantity options	10 mg 1 mg 5 mg
Kategorie	Peptides & Proteins Peptides
Typ	Peptides
Specific against	other
Purity	98.59
Formula	C99H155N31O23
Citations	[1]Zhang, et al.Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family. J Pharmacol Exp Ther. 1998 Jul;286(1):136-41.<br/>[2]Aruna Sharma, et al. Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair. Int Rev Neurobiol. 2012;102:23-45. <br/>[3]I. N. SINGH, et al. Dynorphin A (1–17) induces apoptosis in striatal neurons in vitro through AMPA/kainate receptor-mediated cytochrome c release and caspase-3 activation. Neuroscience. 2003;122(4):1013-23. <br/>[4]K F Hauser, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75. <br/>[5]B J Van de Heijning, et al. Dynorphin-A and vasopressin release in the rat: a structure-activity study. Neuropeptides. 1994 Jun;26(6):371-8. <br/>[6]Takayoshi Mamiya, et al. Dynorphin a (1-13) alleviated stress-induced behavioral impairments in mice. Biol Pharm Bull. 2014;37(8):1269-73.
Smiles	O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC(CNC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	80448-90-4
Similar products	80448-90-4
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Product Description	Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease[1][2].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	2147.48
Clinical Information	Phase 2
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Target	Apoptosis; Caspase; Endogenous Metabolite; Opioid Receptor
Manufacturers Target	Apoptosis; Caspase; Endogenous Metabolite; Opioid Receptor
Isoform	Caspase 3; Human Endogenous Metabolite; κ Opioid Receptor/KOR
Manufacturers Pathway	Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Peptides

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