ArtNr |
HY-P1333-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
80448-90-4 |
Menge |
10 mg |
Quantity options |
10 mg
1 mg
5 mg
|
Kategorie |
|
Typ |
Peptides |
Specific against |
other |
Purity |
98.59 |
Formula |
C99H155N31O23 |
Citations |
[1]Zhang, et al.Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family. J Pharmacol Exp Ther. 1998 Jul;286(1):136-41.<br/>[2]Aruna Sharma, et al. Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair. Int Rev Neurobiol. 2012;102:23-45. <br/>[3]I. N. SINGH, et al. Dynorphin A (1–17) induces apoptosis in striatal neurons in vitro through AMPA/kainate receptor-mediated cytochrome c release and caspase-3 activation. Neuroscience. 2003;122(4):1013-23. <br/>[4]K F Hauser, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75. <br/>[5]B J Van de Heijning, et al. Dynorphin-A and vasopressin release in the rat: a structure-activity study. Neuropeptides. 1994 Jun;26(6):371-8. <br/>[6]Takayoshi Mamiya, et al. Dynorphin a (1-13) alleviated stress-induced behavioral impairments in mice. Biol Pharm Bull. 2014;37(8):1269-73. |
Smiles |
O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC(CNC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
80448-90-4 |
Similar products |
80448-90-4 |
Lieferbar |
|
Product Description |
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease[1][2]. |
StorageTemperature |
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light) |
Shipping |
Blue Ice |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
2147.48 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL |
Target |
Apoptosis; Caspase; Endogenous Metabolite; Opioid Receptor |
Manufacturers Target |
Apoptosis; Caspase; Endogenous Metabolite; Opioid Receptor |
Isoform |
Caspase 3; Human Endogenous Metabolite; κ Opioid Receptor/KOR |
Manufacturers Pathway |
Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling |
Manufacturers Product type |
Peptides |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.