ArtNr |
HY-N0414-100mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
535-83-1 |
Menge |
100 mg |
Quantity options |
100 mg
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.98 |
Formula |
C7H7NO2 |
Citations |
[1]Ilavenil S, et al. Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells. Asian Pac J Trop Med. 2015 Apr;8(4):263-8.<br/>[2]Joanna Folwarczna, et al. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System. Nutrients. 2016 Mar; 8(3): 133.<br/>[3]A Arlt, et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene. 2013 Oct;32(40):4825-35.<br/>[4]Ozçelik B, et al. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm Biol. 2011 Apr;49(4):396-402.<br/>[5]Su Y, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020 Jul 28;483:127-136. |
Smiles |
C[N+]1=CC(C([O-])=O)=CC=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Trigenolline |
Similar products |
535-83-1 |
Lieferbar |
|
Product Description |
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-protein/nucleotide metabolism |
MolecularWeight |
137.14 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Metabolic Disease |
Solubility |
DMSO : 7.14 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL |
Target |
Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV |
Manufacturers Target |
Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV |
Isoform |
Human Endogenous Metabolite |
Manufacturers Pathway |
Anti-infection; Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Natural Products |
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