ArtNr |
HY-B1899-25mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
516-50-7 |
Menge |
25 mg |
Quantity options |
100 mg
10mM/1mL
25 mg
50 mg
|
Kategorie |
|
Typ |
Inhibitor |
Specific against |
other |
Purity |
98.0 |
Formula |
C26H45NO6S |
Citations |
[1]Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000 Mar;30(3):203-9. <br/>[2]Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601. <br/>[3]Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001 Oct;171(2):351-60. <br/>[4]Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6. |
Smiles |
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4]. |
StorageTemperature |
-20°C (Powder, protect from light) |
Shipping |
Blue Ice |
Manufacturers Applications |
Neuroscience-Neurodegeneration |
MolecularWeight |
499.70 |
Clinical Information |
Launched |
Manufacturers Research Area |
Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
Apoptosis; Endogenous Metabolite |
Manufacturers Target |
Apoptosis; Endogenous Metabolite |
Isoform |
Microbial Metabolite |
Manufacturers Pathway |
Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Natural Products |
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