ArtNr |
HY-B0822-50mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
120068-37-3 |
Menge |
50 mg |
Quantity options |
100 mg
10mM/1mL
25 mg
50 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.98 |
Formula |
C12H4Cl2F6N4OS |
Citations |
[1]Das PC, et al. Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. Chem Biol Interact. 2006 Dec 15;164(3):200-14. <br/>[2]Narahashi T, et al. Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals. Pestic Biochem Physiol. 2010 Jun 1;97(2):149-152. |
Smiles |
N#CC1=NN(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)C(N)=C1S(C(F)(F)F)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
120068-37-3 |
Similar products |
120068-37-3 |
Lieferbar |
|
Product Description |
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1][2]. |
StorageTemperature |
4°C (Powder, protect from light, stored under nitrogen) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
437.15 |
Clinical Information |
Launched |
Manufacturers Research Area |
Neurological Disease |
Solubility |
DMSO : 250 mg/mL (ultrasonic) |
Target |
Apoptosis; Cytochrome P450; GABA Receptor |
Manufacturers Target |
Apoptosis; Cytochrome P450; GABA Receptor |
Isoform |
CYP1; CYP2; CYP3 |
Manufacturers Pathway |
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.