ArtNr |
HY-B0280S1-1mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
1092804-88-0 |
Menge |
1 mg |
Quantity options |
10 mg
1 ea
1 mg
5 mg
|
Kategorie |
|
Typ |
Molecules |
Specific against |
other |
Purity |
99.83 |
Citations |
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.<br/>[2]Keating GM. Ranolazine: a review of its use as add-on therapy in patients with chronic stable angina pectoris. Drugs. 2013 Jan;73(1):55-73.<br/>[3]Wang WQ, et al. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.<br/>[4]Zacharowski K, et al. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10. |
Smiles |
O(CC(CN1C(C(N(CC(NC2=C(C)C=CC=C2C)=O)C(C1([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])O)C3=C(OC)C=CC=C3 |
ECLASS 10.1 |
32169090 |
ECLASS 11.0 |
32169090 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
Ranolazine-d8 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
435.59 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cardiovascular Disease; Cancer |
Solubility |
DMSO : 100 mg/mL (ultrasonic; warming) |
Target |
Calcium Channel; Isotope-Labeled Compounds; Sodium Channel |
Manufacturers Target |
Calcium Channel; Isotope-Labeled Compounds; Sodium Channel |
Manufacturers Pathway |
Membrane Transporter/Ion Channel; Neuronal Signaling; Others |
Manufacturers Product type |
Isotope-Labeled Compounds |
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