ArtNr |
HY-18976-5mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
537672-41-6 |
Menge |
5 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.84 |
Formula |
C11H15BrN2O |
Citations |
[1]Mattar P, et al. A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors [J]. Scientific reports, 2021, 11(1): 3858.<br/>[2]Pulya S, et al. Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer [J]. European Journal of Medicinal Chemistry, 2022, 238: 114470.<br/>[3]Dai Y, et al. Classical HDACs in the regulation of neuroinflammation[J]. Neurochemistry International, 2021, 150: 105182.<br/>[4]Yang C X, et al. The inhibitory effects of class I histone deacetylases on hippocampal neuroinflammatory regulation in aging mice with postoperative cognitive dysfunction [J]. European Review for Medical & Pharmacological Sciences, 2020, 24(19).<br/>[5]Pulya S, et al. Selective HDAC3 Inhibitors with Potent In Vivo Antitumor Efficacy against Triple-Negative Breast Cancer [J]. Journal of Medicinal Chemistry, 2023, 66(17): 12033-12058. |
Smiles |
O=C(NNCCCC)C1=CC=C(Br)C=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
UF010 is a selective inhibitor of class I HDAC. UF010 has cytotoxicity to cancer cells and reduces neuroinflammation in the hippocampus. UF010 can be used for the research of neurological diseases[1][2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
271.15 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : ≥ 100 mg/mL |
Target |
HDAC; Interleukin Related; JAK; MyD88; NF-κB; Toll-like Receptor (TLR) |
Manufacturers Target |
HDAC; Interleukin Related; JAK; MyD88; NF-κB; Toll-like Receptor (TLR) |
Isoform |
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; IL-6 |
Manufacturers Pathway |
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt |
Manufacturers Product type |
Reference compound |
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