ArtNr |
HY-16940-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
474-73-7 |
Menge |
10 mg |
Quantity options |
10 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.55 |
Formula |
C27H46O2 |
Citations |
[1]Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209.<br/>[2]M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87.<br/>[3]Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300.<br/>[4]Ishikawa M, et al. 24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure. Sci Rep. 2016 Sep 22;6:33886. |
Smiles |
C[C@H](CC[C@H](O)C(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
24S-OHC; 24S-HC; Cerebrosterol |
Similar products |
474-73-7 |
Lieferbar |
|
Product Description |
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3]. |
StorageTemperature |
-20°C, 3 years (Powder) |
Shipping |
Blue Ice |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
402.65 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Metabolic Disease |
Solubility |
DMSO : 0.1 mg/mL (ultrasonic; warming)|Ethanol : 20 mg/mL (ultrasonic; warming) |
Target |
Endogenous Metabolite; iGluR; LXR |
Manufacturers Target |
Endogenous Metabolite; iGluR; LXR |
Isoform |
Human Endogenous Metabolite; NMDA Receptor |
Manufacturers Pathway |
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Natural Products |
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