ArtNr |
HY-16381A-5mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
396091-76-2 |
Menge |
5 mg |
Kategorie |
|
Typ |
Molecules |
Specific against |
other |
Purity |
99.82 |
Formula |
C60H70N10O11 |
Citations |
[1]Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44.<br>[2]Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77.<br>[3]Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62.<br>[4]Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62.<br>[5]Schmid HA, et, al. Pasireotide (SOM230): development, mechanism of action and potential applications. Mol Cell Endocrinol. 2008 May 14;286(1-2):69-74. |
Smiles |
NCCCC[C@@H](C(N[C@H]1CC2=CC=C(C=C2)OCC3=CC=CC=C3)=O)NC([C@H](NC([C@H](C4=CC=CC=C4)NC([C@H]5N(C([C@H](CC6=CC=CC=C6)NC1=O)=O)C[C@H](OC(NCCN)=O)C5)=O)=O)CC7=CNC8=C7C=CC=C8)=O.CC(O)=O |
ECLASS 10.1 |
32169090 |
ECLASS 11.0 |
32169090 |
UNSPSC |
12000000 |
Alias |
SOM230 (acetate) |
Lieferbar |
|
Product Description |
Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2][3]. |
StorageTemperature |
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen) |
Shipping |
Blue Ice |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
1107.26 |
Clinical_Information |
Launched |
Manufacturers Research_Area |
Cancer; Endocrinology |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C) |
Manufacturers Target |
Somatostatin Receptor |
Pathway |
GPCR/G Protein; Neuronal Signaling |
Manufacturers Product type |
Peptides |
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