ArtNr |
HY-15844-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
149092-50-2 |
Menge |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.02 |
Formula |
C19H15N3O3S2 |
Citations |
[1]Wolfson E, et al. Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer. Cell Death Dis. 2018 Jan 19;9(2):47.<br/>[2]He H, et al. Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation. Cancer J. 2001 May-Jun;7(3):191-202.<br/>[3]Ling J, et al. Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis. Medicine (Baltimore). 2018 Jun;97(22):e10775.<br/>[4]Rahman A, et al. Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. Elife. 2019 Oct 15;8. pii: e50990.<br/>[5]Gazit A, et al. Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J Med Chem. 1993 Nov 12;36(23):3556-64. |
Smiles |
O=C(N)/C(C#N)=C/C1=CC(OC)=C(O)C(CSC2=NC3=CC=CC=C3S2)=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Tyrphostin AG-825 |
Similar products |
149092-50-2 |
Lieferbar |
|
Product Description |
AG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity[1][2][3]. AG825 significantly accelerates apoptosis of human neutrophils[4]. AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development[5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
397.47 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 250 mg/mL (ultrasonic) |
Target |
Apoptosis; EGFR |
Manufacturers Target |
Apoptosis; EGFR |
Isoform |
EGFR/ErbB1/HER1; ErbB2/HER2 |
Manufacturers Pathway |
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK |
Manufacturers Product type |
Reference compound |
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