ArtNr |
HY-15477-5mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
132836-42-1 |
Menge |
5 mg |
Quantity options |
10mM/1mL
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.92 |
Formula |
C20H20BrNO2 |
Citations |
[1]Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.<br/>[2]Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64.<br/>[3]Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65. |
Smiles |
OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors[1][2][3]. |
StorageTemperature |
4°C (Powder, stored under nitrogen) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
386.28 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cardiovascular Disease; Endocrinology |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C) |
Target |
Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K |
Manufacturers Target |
Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K |
Manufacturers Pathway |
GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR |
Manufacturers Product type |
Reference compound |
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