ArtNr |
HY-14933-5mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
524684-52-4 |
Menge |
5 mg |
Quantity options |
10mM/1mL
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.05 |
Formula |
C15H10FNO3 |
Citations |
[1]Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040.<br/>[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.<br/>[3]Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018 May 1. |
Smiles |
OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
ERB-041 |
Lieferbar |
|
Product Description |
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis[1][2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
271.24 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : ≥ 40 mg/mL |
Target |
Apoptosis; Estrogen Receptor/ERR; Wnt |
Manufacturers Target |
Apoptosis; Estrogen Receptor/ERR; Wnt |
Isoform |
ERα; ERβ |
Manufacturers Pathway |
Apoptosis; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
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