ArtNr |
HY-14649S4-5mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
78996-15-3 |
Menge |
5 mg |
Quantity options |
1 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
98.25 |
Formula |
C20H23D5O2 |
Citations |
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.<br/>[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.<br/>[3]Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4):e0153556.<br/>[4]Shaw N, et al. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem. 2003 Oct 24;278(43):41589-92.<br/>[5]Yu S, et al. Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisomeproliferator-activated receptor β/δ (PPARβ/δ). J Biol Chem. 2012 Dec 7;287(50):42195-205. |
Smiles |
O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C([2H])([2H])[2H])C([2H])([2H])CCC1(C)C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Vitamin A acid-d5; all-trans-Retinoic acid-d5; ATRA-d5 |
Lieferbar |
|
Product Description |
Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2][3][4][5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
305.47 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer |
Solubility |
10 mM in DMSO |
Target |
Isotope-Labeled Compounds; PPAR; RAR/RXR |
Manufacturers Target |
Isotope-Labeled Compounds; PPAR; RAR/RXR |
Manufacturers Pathway |
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Isotope-Labeled Compounds |
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